	2-Day PTC Course Sponsored By:

	Date:	June 5-6, 2007
	Course Location:	Hotel Nikko, Dusseldorf, Germany, Immermannestrasse 41, D-40210, Dusseldorf. Tel: +49 (0)211-834-0, Fax: +49 (0)211-161216, website http://www.nikko-hotel.de
	Presentation:	Dr. Marc Halpern - Industrial Phase-Transfer Catalysis Expert
	Course Fee:	$1,495(USD) per participant includes training, manual and lunch on both days of training.
	Early Registration & Payment Fee:	$1,395 (USD) This discount applies only if registration AND payment are received before April 5, 2007
	Course Agenda:	See course Agenda Section

Registration

To register please click on the register button. Registration AND payment of $1,495 USD must be received by May 4, 2007. Payment may be made by check or by wire transfer. An invoice with wire transfer instructions will be sent shortly after registration. An early registration fee of $1,395 (USD) will be honored if registration AND payment are received by April 5, 2007. Checks should be made payable to PTC Communications, Inc., and sent to the address:

PTC Communications, Inc.
PO Box 575
Williamstown, New Jersey 08094 USA

Hotel

Please note that you are responsible for your hotel reservations and payment at the Hotel Nikko, Dusseldorf Germany. The hotel is a 10-minute walk from the main train station. The room rate is 149 Euro per night, so please make your reservations as soon as possible, and no later than May 4, 2007. To make your hotel room reservations, contact the Hotel Nikko at +49 (0)211-834-0 and be sure to say that you are with the "PTC Group"". More details can be found at http://www.nikko-hotel.de.

Meals

Lunch and coffee breaks on both days of the course will be provided (included in the course fees). If you have dietary restrictions (medical, religious or otherwise), please let us know by May 4 and we will be able to order a vegetarian lunch for you.

Additional Questions?

Contact Marc Halpern at tel +1 856-222-1146, fax +1 856-222-1124 or E-mail.


	AGENDA Agenda Overview: "Practical Phase-Transfer Catalysis" is a 2-day course which provides a structured approach and broad applications for developing high-performance and low-cost processes using phase-transfer catalysis. Practical guidelines focus on achieving high yield, high selectivity, short reaction time, avoiding isolation of intermediates, solvent-free PTC, replacing expensive hazardous strong base with inexpensive inorganic base, reducing excess reactants and enhancing safety & environmental performance. Day 1: The first day focuses on choosing reaction conditions and process parameters including catalyst structure, effective catalyst separation, anions & leaving groups, solvent, hydration and agitation. The underlying fundamentals are provided as the basis for resource-efficient screening (3-5 key experiments), development and optimization of PTC systems. Participants often express surprise and appreciation for the systematic guidelines for screening opportunities and selecting & optimizing reaction conditions. Exercises and group discussions reinforce the concepts and practical design of experimental programs. Day 2: On the second day of the course we review and critique > 200 reactions which cover a broad range of base-promoted reactions, substitution reactions, oxidations and reductions. Each application is provided with reaction conditions and yield. Critique of the patents and publications includes discussion of how the reported reaction conditions could have been improved based on the fundamentals and guidelines learned on Day 1 of the course.

AGENDA

Agenda Overview:

"Practical Phase-Transfer Catalysis" is a 2-day course which provides a structured approach and broad applications for developing high-performance and low-cost processes using phase-transfer catalysis. Practical guidelines focus on achieving high yield, high selectivity, short reaction time, avoiding isolation of intermediates, solvent-free PTC, replacing expensive hazardous strong base with inexpensive inorganic base, reducing excess reactants and enhancing safety & environmental performance.

Day 1:

The first day focuses on choosing reaction conditions and process parameters including catalyst structure, effective catalyst separation, anions & leaving groups, solvent, hydration and agitation. The underlying fundamentals are provided as the basis for resource-efficient screening (3-5 key experiments), development and optimization of PTC systems. Participants often express surprise and appreciation for the systematic guidelines for screening opportunities and selecting & optimizing reaction conditions. Exercises and group discussions reinforce the concepts and practical design of experimental programs.

Day 2:

On the second day of the course we review and critique > 200 reactions which cover a broad range of base-promoted reactions, substitution reactions, oxidations and reductions. Each application is provided with reaction conditions and yield. Critique of the patents and publications includes discussion of how the reported reaction conditions could have been improved based on the fundamentals and guidelines learned on Day 1 of the course.

Day 1
8:30	Registration
8:45	Introduction Phase-Transfer Catalysis Overview PTC Mechanism "I-Reaction" and "T-Reaction" The PTC Rate Matrix Introduction to Understanding Interactions Between Catalyst, Hydration, Solvent and Anions
10:15	Break
10:30	Choosing Process Parameters Choosing Catalyst Structure Activity Relationships including systematic approach for predicting and selecting catalyst for reactivity effective catalyst separation methods including minimizing residue and waste catalyst recycle catalyst stability toxicity availability
12:00	Lunch
1:15	Choosing Process Parameters - continued Anions, Leaving Group and Catalyst Poisoning Hydration (dramatic effects and control) Practical Aspects of Solvent Solvent-Free PTC Agitation "Third Phase" PTC (not triphase PTC)
2:45	Break
3:00	Practical Guidelines Guidelines for Identifying, Evaluating and Optimizing New PTC Applications A 3-5 Experiment Program for Screening & Resource-Efficient R&D Patentable Opportunities Identifying Opportunities The 60-Second PTC Test
4:00	Group Exercises
4:45	Break for Evening
Day 2
8:45	Applications - Strong Base Reactions C-Alkylation Chiral Alkylation O-Alkylation S-Alkylation N-Alkylation
10:15	Break
10:30	Applications - Strong Base Reactions - continued Michael Addition Aldol Condensation Wittig, Darzens Other Condensations Dehydrohalogenation Carbene Reactions Applications - Nucleophilic Substitutions Esterification Transesterification O-Acylation & Thiophosphorylation Use of Water-Sensitive Reactants in PTC Substitutions
12:00	Lunch
1:15	Nucleophilic Substitutions - continued Cyanide Azide Fluoride Other nucleophilic aliphatic and aromatic substitutions Applications - Oxidation Oxidations Hydrogen Peroxide Hypochlorite Other oxidizing agents Epoxidations
2:30	Break
2:45	Applications - Reduction & Other Reductions Borohydride Hydrogenation Other reducing agents Transition Metal Co-Catalysis Additional PTC reactions and exercises
4:00	Course Conclusion